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10.1161/ATVBAHA.107.153742 328 WilsonA
It's marketed and sold as a dietary supplement, not a prescription medication
Begin with every other day (or only 2-3x per week) and work up to daily applications
The article reports nausea in approximately 25 to 44 percent of patients on semaglutide at maintenance doses, and 25 to 33 percent for tirzepatide with vomiting in 1 to 6 percent, depending on dose and the population studied
A subgroup analysis by weight reduction iced the case for proportionate benefit of symptom relief and less inflammation (by biomarkers) as a function of weight loss These are striking results for people with HFpEf given the only other drugs that have thus far shown benefit are the sodium-glucose cotransporter 2 (SGLT2) inhibitors
Appetite reduction is common
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